MATERIAL SAFETY DATA SHEET
R402B
CHEMICAL PRODUCT/COMPANY IDENTIFICATION
Material Identification
Product Use: Refrigerant
Tradenames and Synonyms:
PENTAFLUOROETHANE & CHLORODIFLUOROMETHANE
Company: BEST INC., LIMITED.
Add.: Rooms 1318-20, 13/F Hollywood Plaza, 610 Nathan Road, Mongkok, Kowloon, Hong Kong
Tel: +852-30774337 Fax:+852-30774338
COMPOSITION/INFORMATION ON INGREDIENTS
Components: ETHANE, PENTAFLUOROETHANE (HFC-125) 354-33-6 38 %
Material CAS Number % : * 75-45-6
*METHANE, CHLORODIFLUOROMETHANE (HCFC-22) 60 %
PROPANE 74-98-6 2 %
HAZARDS IDENTIFICATION
Potential Health Effects
Inhalation of high concentrations of vapor is harmful and may cause heart irregularities, unconsciousness, or death. Intentional misuse or deliberate inhalation may cause death without warning. Vapor reduces oxygen available for breathing and is heavier than air. Liquid contact can cause frostbite.
HUMAN HEALTH EFFECTS:
Overexposure to the vapors by inhalation may include temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination, and loss of consciousness. Higher exposures to the vapors may cause temporary alteration of the heart’s electrical activity with irregular pulse, palpitations, or inadequate circulation. Fatality may occur from gross overexposure. Skin contact with the liquid may cause frostbite.
Individuals with preexisting diseases of the central nervous or cardiovascular system may have increased susceptibility to the toxicity of increased exposures.
Carcinogenicity Information
None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH as a carcinogen.
FIRST AID MEASURES
First Aid
INHALATION
If inhaled, immediately remove to fresh air. Keep person calm. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
SKIN CONTACT
Flush area with lukewarm water. Do not use hot water. If frostbite has occurred, call a physician.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician.
INGESTION
Not a probable route. However, in case of accidental ingestion, call a physician.
Notes to Physicians
THIS MATERIAL MAY MAKE THE HEART MORE SUSCEPTIBLE TO ARRHYTHMIAS. Catecholamines such as adrenaline, and other compounds having similar effects, should be reserved for emergencies and then used only with special caution.
FIRE FIGHTING MEASURES
Flammable Properties
Flash Point : No flash point
Flammable Limits in Air, % by Volume:
LEL : None per ASTM E681
UEL : None per ASTM E681
Autoignition: Not determined
Fire and Explosion Hazards:
Cylinders may rupture under fire conditions. Decomposition may occur.
Contact of welding or soldering torch flame with high concentrations of refrigerant can result in visible changes in the size and color of torch flames. This flame effect will only occur in concentrations of product well above the recommended exposure limit, therefore stop all work and ventilate to disperse refrigerant vapors from the work area before using any open flames.
R-402B is not flammable in air at temperatures up to 100
deg C (212 deg F) at atmospheric pressure. However, mixtures of R-402B with high concentrations of air at elevated pressure and/or temperature can become combustible
in the presence of an ignition source. R-402B can also become combustible in an oxygen enriched environment (oxygen concentrations greater than that in air). Whether a mixture
containing R-402B and air, or R-402B in an oxygen enriched atmosphere becomes combustible depends on the inter-relationship of 1) the temperature 2) the pressure, and 3) the proportion of oxygen in the mixture. In general, R-402B should not be allowed to exist with air above atmospheric pressure or at high temperatures; or in an oxygen enriched environment. For example: R-402B should NOT be mixed with air under pressure for leak testing or other purposes.
Experimental data have also been reported which indicate combustibility of HCFC-22, a component in this blend, in the presence of chlorine.
Extinguishing Media
As appropriate for combustibles in area.
Fire Fighting Instructions
Keep cylinders cool with water spray or fog. Self-contained breathing apparatus (SCBA) is required if cylinders rupture and contents are released under fire conditions. Water runoff should be contained and neutralized prior to release.
ACCIDENTAL RELEASE MEASURES
Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with clean-up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Accidental Release Measures
Remove open flames. Use self-contained breathing apparatus (SCBA) for large spills or releases.
HANDLING AND STORAGE
Handling (Personnel)
Avoid breathing vapors. Avoid liquid contact with skin or eyes. Use with sufficient ventilation to keep employee exposure below the recommended limits. Avoid prolonged or
repeated exposure. Wash thoroughly after handling.
Storage: Clean, dry area. Do not heat above 52 deg C (125 deg F).
EXPOSURE CONTROLS/PERSONAL PROTECTION
Engineering Controls
Refrigerant concentration monitors may be necessary to determine vapor concentrations in work areas prior to use of torches or other open flames, or if employees are entering enclosed areas.
Use with sufficient ventilation to keep employee exposure below the recommended exposure limit. Local exhaust should be used if large amounts are released. Mechanical ventilation should be used in low or enclosed places.
Personal Protective Equipment
Impervious gloves should be used to avoid prolonged or repeated exposure. Chemical splash goggles should be available for use as needed to prevent eye contact. Under normal manufacturing conditions, no respiratory protection is required when using this product. Self-contained breathing apparatus (SCBA) is required if a large release occurs.
Exposure Guidelines
Applicable Exposure Limits
ETHANE, PENTAFLUOROETHANE (HFC-125)
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 1000 ppm, 8 & 12 Hr. TWA
WEEL (AIHA) : 1000 ppm, 4900 mg/m3, 8 Hr. TWA
METHANE, CHLORODIFLUOROMETHANE (HCFC-22)
PEL (OSHA) : None Established
TLV (ACGIH) : 1,000 ppm, 3,540 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : None Established
PROPANE
PEL (OSHA) : 1,000 ppm, 1,800 mg/m3, 8 Hr. TWA
TLV (ACGIH) : 2500 ppm, 8 Hr. TWA
AEL * (DuPont) : None Established
* AEL is DuPont’s Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence.
PHYSICAL AND CHEMICAL PROPERTIES
Physical Data
Boiling Point : -47.4 C (-53.3 F) Average
Vapor Pressure : 179.6 psia at 25 deg C (77 deg F)
% Volatiles : 100 WT%
Evaporation Rate : (CCl4 = 1)
Solubility in Water : Not determined
Odor : Slight ethereal
Form : Liquefied gas
Color : Clear, colorless
Density : 1.14 gm/cc at 25 deg C (77 deg F) –
Liquid
STABILITY AND REACTIVITY
Chemical Stability
Material is stable. However, avoid open flames and high temperatures. Incompatibility with Other Materials
Incompatible with alkali or alkaline earth metals -powdered Al, Zn, Be, etc.
Decomposition
Decomposition products are hazardous. "SUVA" HP81 can be decomposed by high temperatures (open flames, glowing metal surfaces, etc.) forming hydrochloric and hydrofluoric acids and possibly carbonyl halides. These materials are toxic and irritating. Contact should be avoided.
Polymerization
Polymerization will not occur.
TOXICOLOGICAL INFORMATION
Animal Data
The blend is untested.
ETHANE, PENTAFLUORO
Inhalation 4 hour ALC: > 709,000 ppm in rats Single, high inhalation exposures caused lethargy, decreased activity, labored breathing and weight loss. Weak cardiac sensitization effect, a potentially fatal disturbance of heart rhythm caused by a heightened sensitivity to the
action of epinephrine. Lowest-Observed-Adverse-Effects-Level for cardiac sensitization: 100,000 ppm. Repeated exposure caused: No significant toxicological effects. No-Observed-Adverse-Effect-Level(NOAEL): 50,000 ppm
No animal data are available to define carcinogenic, developmental or reproductive hazards. In animal testing this material has not caused developmental toxicity. HFC-125 does not produce genetic damage in bacterial or mammalian cell cultures or when tested in animals (not tested for heritable genetic damage).
METHANE, CHLORODIFLUORO
Inhalation 4-hour LC50: 220,000 ppm in rats
The compound is a skin irritant and a slight eye irritant, but is not a skin sensitizer in animals.
Effects from single high exposures include central nervous system depression, anesthesia, rapid breathing, lung congestion and microscopic liver changes. Cardiac sensitization occurred in dogs at 50,000 ppm or greater from the action of exogenous epinephrine.
No toxic effects or abnormal histopathological observations occurred in rats repeatedly exposed to concentrations ranging from 10,000 to 50,000 ppm (v/v). Long-term exposures to 50,000 ppm (v/v) of vapors produced organ weight increases and a decrease in body weight gain, but no increased mortality or adverse hematological effects.
In chronic inhalation studies, HCFC-22, at a concentration of 50,000 ppm (v/v), produced a small, but statistically significant increase of late-occurring tumors involving salivary glands in male rats, but not female rats or male or female mice. In the same studies, no increased incidence of tumors was seen in either species at concentrations of 10,000 ppm or 1000 ppm (v/v).
Long-term administration in corn oil produced no effects on body weight or mortality.
HCFC-22 was mutagenic in some strains of bacteria in bacterial cell cultures, but not mammalian cell cultures or animals. It did not cause heritable genetic damage in mammals.
A slight, but significant increase in developmental toxicity was observed at high concentrations (50,000 ppm) of HCFC-22, a concentration which also produced toxic effects in the adult animal. Based on these findings, and other negative developmental studies, HCFC-22 is not considered a unique hazard to the conceptus. Studies of the effects of HCFC-22 on male reproductive performance have been negative. Specific studies to evaluate the effect on female reproductive performance have not been conducted, however, limited information obtained from studies on developmental toxicity do not indicate adverse effects on female reproductive performance at concentrations up to 50,000 ppm.
PROPANE
Toxicity in animals occurring only with inhalation exposures at high concentrations (10% or greater) include cardiac sensitization, analgesia, irregular respiration and hypotension. No animal test reports are available to define carcinogenic, developmental, or reproductive hazards. Tests in bacteria cell cultures demonstrate no mutagenic activity.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity:
HCFC-22
48 hour EC50 - Daphnia magna: 433 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Comply with Federal, State, and local regulations. Reclaim by distillation or remove to a permitted waste disposal facility.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO/IATA
Proper Shipping Name : Liquefied Gas N.O.S.
(Chlorodifluoromethane and Pentafluoroethane)
Hazard Class : 2.2
UN No. : 3163
Label(s) : Nonflammable Gas
Shipping Containers: Tank Cars. Cylinders. Ton Tanks
UN # : 3163
TDG Class : 2.2
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REGULATORY INFORMATION
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U.S. Federal Regulations
TSCA Inventory Status : Reported/Included.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : No
Fire : No
Reactivity : No
Pressure : Yes
HAZARDOUS CHEMICAL LISTS
SARA Extremely Hazardous Substance: No
CERCLA Hazardous Substance : No
SARA Toxic Chemical - See Components Section
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NPCA-HMIS Rating
Health : 1
Flammability : 0
Reactivity : 1
Personal Protection rating to be supplied by user depending on use conditions.
Additional Information
MEDICAL USE: CAUTION: Do not use in medical applications involving permanent implantation in the human body. For other medical applications see DuPont CAUTION Bulletin No. H-50102.
